Guillermo Alexander's current research focuses on the study of pro- and anti-inflammatory cytokines, amino acids, neuroactive peptides and biogenic amines found in the blood and cerebrospinal fluid of patients with complex regional pain syndrome (CRPS)/reflex sympathetic dystrophy (RSD). These studies could shed light on the mechanisms that bring about exaggerated pain and could aid in the development of more effective treatment modalities.

In another series of studies he is utilizing a transgenic mouse model for ALS to study the effect of genetic background on the severity of the disease.

Recent Publications

"Changes in Plasma levels of Cytokines and their Soluble Receptors in Patients with Complex Regional Pain Syndrome"
Alexander GM, Peterlin BL,  Perreault MJ, Grothusen JR and Schwartzman RJ
J. Pain 13(1): 10-20, 2012

"Effect of Genetic Background on Phenotype Variability in Transgenic Mouse Models of Amyotrophic Lateral Sclerosis: A window of opportunity in the search for genetic modifiers"
Heiman-Patterson TD, Blankenhorn EP, Deitch, JS, Alexander G, Sher R, Cox G, Kunst CB and Maragakis NJ
Amyotroph Lateral Scler. 12(2):79-86, 2011

"Elevated blood levels of inflammatory monocytes (CD14+CD16+) in patients with Complex Regional Pain Syndrome"
Ritz B, Alexander GM, Nogusa S, Perreault MJ, Peterlin BL, Grothusen JR and Schwartzman RJ
Clinical Experimental Immunology 164(1):108-17, 2011

"MicroRNA modulation in complex regional pain syndrome"
Irina A Orlova, Guillermo M Alexander, Rehman A Qureshi, Ahmet Sacan, Alessandro Graziano, James E Barrett, Robert J Schwartzman and Seena K Ajit.
Journal of Translational Medicine, 9:195, 2011

"Neuropsychological deficits associated with complex regional pain syndrome"
Libon DJ, Schwartzman RJ, Eppig J, Wambach D, Brahin E, Peterline BL, Alexander G 
Journal of the International Neuropsychological Society 16:566-573, 2010

"Spinal Cord Histopathological Alterations in a Patient with Longstanding Complex Regional Pain Syndrome"
Del Valle L, Schwartzman RJ and Alexander G
Brain Behavior and Immunity, 23: 85–91, 2009

"Efficacy of 5-day continuous lidocaine infusion for the treatment of refractory complex regional pain syndrome"
Schwartzman RJ, Patel M, Grothusen JR, Alexander GM
Pain Med. 10(2):401-12, 2009

"High Dose Cyclophosphamide in the Treatment of Multiple Sclerosis"
Schwartzman RJ,  Simpkins N, Alexander GM, Reichenberger ER, Ward K, Lindenberg N,  Topolsky DL, Crilley P
CNS Neurosci Ther, 15:118-127, 2009

"Self-reported vs measured body mass indices in migraineurs"
Katsnelson MJ, Peterlin BL, Rosso AL, Alexander GM, Erwin KL
Headache 49(5):663-668, 2009

"The Natural History of Complex Regional Pain Syndrome"
Schwartzman RJ, Erwin KL and Alexander GM
Clin J Pain. 25:273-80, 2009.

"Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study"
Schwartzman RJ, Alexander GM, Grothusen JR, Paylor T, Reichenberger E and Perreault M
Pain 147:107-115, 2009.